Synthesis and in vitro activity of ROMP-based polymer nanoparticles
نویسندگان
چکیده
منابع مشابه
Synthesis and In vitro activity of ROMP-based polymer nanoparticles.
A new type of polymer nanoparticle (PNP) containing a high density of covalently linked doxorubicin, attached via a non-cleavable amine linkage (amine-linked Dox-PNP) was prepared. Together with a previously reported cleavable carbamate-linked Dox-PNP, this new amine-linked Dox-PNP was subsequently evaluated against free doxorubicin for its cytotoxicity and inhibitory effects on SKNSH wild-type...
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attempts have been made to prepare nanoparticles based on poly(lactic-co-glycolic acid) (plga) and doxorubicin. biological evaluation and physio-chemical characterizations were performed to elucidate the effects of initial drug loading and polymer composition on nanoparticle properties and its antitumor activity. plga nanoparticles were formulated by sonication method. lactide/glycolide ratio a...
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ژورنال
عنوان ژورنال: Journal of Materials Chemistry
سال: 2009
ISSN: 0959-9428,1364-5501
DOI: 10.1039/b817511j